| Region | Level | Instrument | Chair | Name | School |
| 6 | SR | Flute | 01 | Madeline George | James F. Byrnes High School |
| 6 | SR | Flute | 02 | David Goforth | Clover High School |
| 6 | SR | Flute | 03 | Gabriela Lagos | Dorman High School |
| 6 | SR | Flute | 04 | Sunny Harrison | James F. Byrnes High School |
| 6 | SR | Flute | 05 | Nevaeh Nash | Dorman High School |
| 6 | SR | Flute | 06 | Dylan Thompson | S.C. Governor’s School for the Arts and Humanities – Region 6 |
| 6 | SR | Flute | 07 | Avery Hofman | Clover High School |
| 6 | SR | Flute | 08 | Charlie Sok | Chapman High School |
| 6 | SR | Flute | 09 | Max Mortenson | James F. Byrnes High School |
| 6 | SR | Flute | 10 | Shiena Rodgers | James F. Byrnes High School |
| 6 | SR | Flute | 11 | Kylee Stacker | James F. Byrnes High School |
| 6 | SR | Flute | 12 | Noah Rybak | James F. Byrnes High School |
| 6 | SR | Flute | A1 | Aliyah Wilson | Spartanburg High School |
| 6 | SR | Flute | A2 | Addison Copeland | Dorman High School |
| 6 | SR | Flute | A3 | Lily Staton | Landrum High School |
| 6 | SR | Flute | A4 | Isabella Desrocher | James F. Byrnes High School |
| 6 | SR | Flute | A5 | Avery Sanders | Dorman High School |
| 6 | SR | Flute | A6 | Fernando Sosa | Mid-Carolina High School |
| 6 | SR | Oboe | 01 | Theo Tice | James F. Byrnes High School |
| 6 | SR | Oboe | 02 | Jillian West | Chapman High School |
| 6 | SR | Oboe | 03 | Ella Bowen | Dorman High School |
| 6 | SR | Oboe | 04 | Brenna Clinton | York Comprehensive High School |
| 6 | SR | Oboe | A1 | Annaka Lyda | Spartanburg High School |
| 6 | SR | Oboe | A2 | Kyri Johnson | Landrum High School |
| 6 | SR | Bassoon | 01 | Micah Whitfield | Boiling Springs High School |
| 6 | SR | Bassoon | 02 | Killian McDaniel | Spartanburg High School |
| 6 | SR | Bassoon | 03 | Emelyn Pacheco-Vera | York Comprehensive High School |
| 6 | SR | Clarinet | 01 | Alaina Ramsey | James F. Byrnes High School |
| 6 | SR | Clarinet | 02 | Bryan Avalos-Barrera | Dorman High School |
| 6 | SR | Clarinet | 03 | Bri Hand | James F. Byrnes High School |
| 6 | SR | Clarinet | 04 | Kinsley Pearson | James F. Byrnes High School |
| 6 | SR | Clarinet | 05 | Sarah Coleman | James F. Byrnes High School |
| 6 | SR | Clarinet | 06 | Leah Shnitser | Chapman High School |
| 6 | SR | Clarinet | 07 | Kendra Decena | Dorman High School |
| 6 | SR | Clarinet | 08 | Misa Desai | James F. Byrnes High School |
| 6 | SR | Clarinet | 09 | Carolyn Ard | Clover High School |
| 6 | SR | Clarinet | 10 | Mary Franklin Gilman | Spartanburg Day School |
| 6 | SR | Clarinet | 11 | Stella Parham | James F. Byrnes High School |
| 6 | SR | Clarinet | 12 | Suzanna Mikhaylenko | Chapman High School |
| 6 | SR | Clarinet | 13 | Leah Bray | Dorman High School |
| 6 | SR | Clarinet | 14 | Liliana Ramirez | Dorman High School |
| 6 | SR | Clarinet | 15 | Ellie Wegiel | Clover High School |
| 6 | SR | Clarinet | 16 | Audrey Matthews | James F. Byrnes High School |
| 6 | SR | Clarinet | 17 | Amy Yudich | Chapman High School |
| 6 | SR | Clarinet | 18 | Bella Fusaro | Clover High School |
| 6 | SR | Clarinet | 19 | Riley Howard | Dorman High School |
| 6 | SR | Clarinet | 20 | Olivia Webb | Boiling Springs High School |
| 6 | SR | Clarinet | 21 | Juanita Cuevas | Clover High School |
| 6 | SR | Clarinet | 22 | David Armistead | Chapman High School |
| 6 | SR | Clarinet | 23 | Kaylyn Senn | Chesnee High School |
| 6 | SR | Clarinet | 24 | Ella Ray | Clover High School |
| 6 | SR | Clarinet | A1 | Audrey Meuse | Chapman High School |
| 6 | SR | Clarinet | A2 | Hayden Johansen | Clover High School |
| 6 | SR | Clarinet | A3 | Ava Hill | Chesnee High School |
| 6 | SR | Clarinet | A4 | Jimena Lopez | Chapman High School |
| 6 | SR | Clarinet | A5 | Celine Cetrone | Clover High School |
| 6 | SR | Clarinet | A6 | Rhylea Neves | Chapman High School |
| 6 | SR | Clarinet | A7 | Alexis Garza-Torres | Chesnee High School |
| 6 | SR | Bass Clarinet | 01 | Bryce Harshbarger | Clover High School |
| 6 | SR | Bass Clarinet | 02 | Derek Gonzalez | Clover High School |
| 6 | SR | Bass Clarinet | 03 | Serenity Haddad | Clover High School |
| 6 | SR | Bass Clarinet | 04 | Colton Tenry | Clinton High School |
| 6 | SR | Bass Clarinet | A1 | Vacari Sullivan | James F. Byrnes High School |
| 6 | SR | Bass Clarinet | A2 | Sadie Jones | Chesnee High School |
| 6 | SR | Contra Clarinet | 01 | Tamira Hopkins-Smith | Clover High School |
| 6 | SR | Alto Sax | 01 | Zachary Kilkelly | Clover High School |
| 6 | SR | Alto Sax | 02 | Daelyn Thomas | Clover High School |
| 6 | SR | Alto Sax | 03 | Colton Domer | Clover High School |
| 6 | SR | Alto Sax | 04 | Tyler Willis | James F. Byrnes High School |
| 6 | SR | Alto Sax | 05 | Jordan Galan | York Comprehensive High School |
| 6 | SR | Alto Sax | 06 | Caleb Garrett | Chapman High School |
| 6 | SR | Alto Sax | 07 | Christian Roldan | York Comprehensive High School |
| 6 | SR | Alto Sax | 08 | Jared Chacon | Landrum High School |
| 6 | SR | Alto Sax | A1 | Sam Slater | Chapman High School |
| 6 | SR | Alto Sax | A2 | Javon Brown | James F. Byrnes High School |
| 6 | SR | Alto Sax | A3 | Landon Cantrell | Chapman High School |
| 6 | SR | Tenor Sax | 01 | Lacey Billings | York Comprehensive High School |
| 6 | SR | Tenor Sax | 02 | Edwin Espino | Boiling Springs High School |
| 6 | SR | Tenor Sax | 03 | Samuel Wolnik | Clover High School |
| 6 | SR | Tenor Sax | 04 | Kevin Quinones | Clover High School |
| 6 | SR | Tenor Sax | A1 | Madelina Tabia | James F. Byrnes High School |
| 6 | SR | Bari Sax | 01 | Patrick Coyle | Clover High School |
| 6 | SR | Bari Sax | 02 | Noah Harrell | York Comprehensive High School |
| 6 | SR | Bari Sax | A1 | Colt Belcher | James F. Byrnes High School |
| 6 | SR | Trumpet | 01 | Erin Alsup | Chapman High School |
| 6 | SR | Trumpet | 02 | Alex Aull | Clover High School |
| 6 | SR | Trumpet | 03 | Deacon Henson | Chapman High School |
| 6 | SR | Trumpet | 04 | Gabe Rini | James F. Byrnes High School |
| 6 | SR | Trumpet | 05 | Michael Bustos | James F. Byrnes High School |
| 6 | SR | Trumpet | 06 | James Gilkeson | Clover High School |
| 6 | SR | Trumpet | 07 | Nate Hart | James F. Byrnes High School |
| 6 | SR | Trumpet | 08 | Zachary Tiller | Clover High School |
| 6 | SR | Trumpet | 09 | Matthew Baker | Boiling Springs High School |
| 6 | SR | Trumpet | 10 | Adam Feld | Clover High School |
| 6 | SR | Trumpet | 11 | Edwyn Semerenko | Boiling Springs High School |
| 6 | SR | Trumpet | 12 | Ivy Traylor | York Comprehensive High School |
| 6 | SR | Trumpet | 13 | Zander Snyder | James F. Byrnes High School |
| 6 | SR | Trumpet | 14 | Sophie Graden | James F. Byrnes High School |
| 6 | SR | Trumpet | 15 | Colton Pitts | Boiling Springs High School |
| 6 | SR | Trumpet | 16 | Rodolfo Yanez-Dera | Dorman High School |
| 6 | SR | Trumpet | A1 | MaKenzie Foster | High Point Academy |
| 6 | SR | Trumpet | A2 | Mary Kate McNeill | Clover High School |
| 6 | SR | Trumpet | A3 | Reid Barnado | Union County High School |
| 6 | SR | Trumpet | A4 | Nikolas Garner | Union County High School |
| 6 | SR | Trumpet | A5 | Zachary Wade | Spartanburg High School |
| 6 | SR | Trumpet | A6 | Caleb Lazarek | Clover High School |
| 6 | SR | Horn | 01 | Oliver Querin | Spartanburg High School |
| 6 | SR | Horn | 02 | Jonathan May | James F. Byrnes High School |
| 6 | SR | Horn | 03 | Tavares Hubbard | James F. Byrnes High School |
| 6 | SR | Horn | 04 | Margaret Work | Clover High School |
| 6 | SR | Horn | 05 | Michael Smith | Chapman High School |
| 6 | SR | Horn | 06 | Ben West | Boiling Springs High School |
| 6 | SR | Horn | 07 | Matthew Nix | James F. Byrnes High School |
| 6 | SR | Horn | 08 | Bryson Miller | James F. Byrnes High School |
| 6 | SR | Horn | A1 | Who Gressling | York Comprehensive High School |
| 6 | SR | Horn | A2 | Morgan Moody | Dorman High School |
| 6 | SR | Horn | A3 | John Bradley | Dorman High School |
| 6 | SR | Horn | A4 | Brentley Odom | James F. Byrnes High School |
| 6 | SR | Trombone | 01 | Bryson Cox | Dorman High School |
| 6 | SR | Trombone | 02 | Noah Bullard | James F. Byrnes High School |
| 6 | SR | Trombone | 03 | Giovanni Notarianni | James F. Byrnes High School |
| 6 | SR | Trombone | 04 | Desmond Lancaster | Clover High School |
| 6 | SR | Trombone | 05 | Anthony Pena | Chapman High School |
| 6 | SR | Trombone | 06 | Silver Page | Dorman High School |
| 6 | SR | Trombone | 07 | Wyatt Morin | York Comprehensive High School |
| 6 | SR | Trombone | 08 | Bax Potter | Woodruff High School |
| 6 | SR | Trombone | 09 | Aidan Cahill | Clover High School |
| 6 | SR | Trombone | A1 | Autumn Hull | Boiling Springs High School |
| 6 | SR | Trombone | A2 | Hayden Fortner | Clover High School |
| 6 | SR | Trombone | A3 | Curtis Efird | Clover High School |
| 6 | SR | Trombone | A4 | Bryson Olmstead | Boiling Springs High School |
| 6 | SR | Trombone | A5 | Ryu Jeffcoat | James F. Byrnes High School |
| 6 | SR | Euphonium | 01 | Nicholas Rodriguez | Boiling Springs High School |
| 6 | SR | Euphonium | 02 | Jake Boykin | James F. Byrnes High School |
| 6 | SR | Euphonium | 03 | CJ Fleming | James F. Byrnes High School |
| 6 | SR | Euphonium | 04 | Lauren Williams | Clover High School |
| 6 | SR | Euphonium | A1 | John Olaya | York Comprehensive High School |
| 6 | SR | Euphonium | A2 | Aniya Hart | York Comprehensive High School |
| 6 | SR | Tuba | 01 | Braden Osteen | Clover High School |
| 6 | SR | Tuba | 02 | Justin Telemaque | James F. Byrnes High School |
| 6 | SR | Tuba | 03 | Ethan Barkaway | Clover High School |
| 6 | SR | Tuba | 04 | Ethan Norris | Clover High School |
| 6 | SR | Tuba | 05 | Tyler Sullivan | Spartanburg High School |
| 6 | SR | Tuba | 06 | Emilio Perez-Salas | Chesnee High School |
| 6 | SR | Tuba | 07 | Maggie Hullender | York Comprehensive High School |
| 6 | SR | Tuba | 08 | Carlos Garcia-Reyes | York Comprehensive High School |
| 6 | SR | Tuba | A1 | Blake Beard | York Comprehensive High School |
| 6 | SR | Tuba | A2 | Chloe Adams | Clover High School |
| 6 | SR | Tuba | A3 | Nathaniel Jean | Dorman High School |
| 6 | SR | Tuba | A4 | Johana Ojeda-Ortega | Chapman High School |
| 6 | SR | Bass Trombone | 01 | Leobardo Gutierrez | Dorman High School |
| 6 | SR | Bass Trombone | A1 | Reid Brown | Laurens District 55 High School |
| 6 | SR | Percussion | 01 | Zion Price | Clover High School |
| 6 | SR | Percussion | 02 | Colton Goff | Clover High School |
| 6 | SR | Percussion | 03 | Haleigh Stewart | Clover High School |
| 6 | SR | Percussion | 04 | Owen Montgomery | James F. Byrnes High School |
| 6 | SR | Percussion | 05 | Josiah Kee | Clover High School |
| 6 | SR | Percussion | 06 | Tessa Shaw | Clover High School |
| 6 | SR | Percussion | 07 | Colleen Breslin | Clover High School |
| 6 | SR | Percussion | A1 | Benjamin Ricks | York Comprehensive High School |
| 6 | SR | Percussion | A2 | Jeremiah Chang | Clover High School |
| 6 | SR | Percussion | A3 | Julien Garcia | Clover High School |
| 6 | SR | Percussion | A4 | Alyssa Williams | Union County High School |
| 6 | SR | Timpani | 01 | Will Jones | James F. Byrnes High School |
| 6 | SR | Timpani | A1 | Brayden Stevens | Dorman High School |