| Region | Level | Instrument | Chair | Name | School |
| 4 | SR | Flute | 01 | Alysha Kindred | Charleston School of the Arts High School |
| 4 | SR | Flute | 02 | Chase Spicer | Wando High School |
| 4 | SR | Flute | 03 | Sarah Whitaker | Wando High School |
| 4 | SR | Flute | 04 | Danielle Swehla | Summerville High School |
| 4 | SR | Flute | 05 | Lauren Hagood | Charleston School of the Arts High School |
| 4 | SR | Flute | 06 | Niya Brown | Wando High School |
| 4 | SR | Flute | 07 | Keilie Perry | Summerville High School |
| 4 | SR | Flute | 08 | Abigail Doll | East Cooper Homeschool Band |
| 4 | SR | Flute | 09 | Cassondra Lester | Wando High School |
| 4 | SR | Flute | 10 | Evan Chapman | Bluffton High School |
| 4 | SR | Flute | 11 | Jessica Tisdale | James Island Charter High School |
| 4 | SR | Flute | 12 | Kyra Smith | Summerville High School |
| 4 | SR | Flute | A1 | Riley Mazey | May River High School |
| 4 | SR | Flute | A2 | Sean Capers | Fort Dorchester High School |
| 4 | SR | Oboe | 01 | Morgan Young | Wando High School |
| 4 | SR | Oboe | 02 | Emily Cook | Wando High School |
| 4 | SR | Bassoon | 01 | Shad Burkett | Summerville High School |
| 4 | SR | Clarinet | 01 | Henry King | Charleston School of the Arts High School |
| 4 | SR | Clarinet | 02 | Lauren Giordano | Summerville High School |
| 4 | SR | Clarinet | 03 | Mark Steffan | James Island Charter High School |
| 4 | SR | Clarinet | 04 | Chase Miller | Wando High School |
| 4 | SR | Clarinet | 05 | Ethan Lo | Wando High School |
| 4 | SR | Clarinet | 06 | Alayna Mulligan | Wando High School |
| 4 | SR | Clarinet | 07 | Alexia Charles | Fort Dorchester High School |
| 4 | SR | Clarinet | 08 | Caroline Walker | S.C. Governor’s School for the Arts and Humanities – REGION 4 |
| 4 | SR | Clarinet | 09 | Olivia Lopez | Charleston School of the Arts High School |
| 4 | SR | Clarinet | 10 | Jordan Talley | Wando High School |
| 4 | SR | Clarinet | 11 | Celine Corkill | Summerville High School |
| 4 | SR | Clarinet | 12 | Alexis Lewis | Fort Dorchester High School |
| 4 | SR | Clarinet | 13 | Jordan Alston | Wando High School |
| 4 | SR | Clarinet | 14 | Colleen Pia | Ashley Ridge High School |
| 4 | SR | Clarinet | 15 | Lea Bell | Wando High School |
| 4 | SR | Clarinet | 16 | Isabella Lindon | Charleston School of the Arts High School |
| 4 | SR | Clarinet | 17 | Bradley Cole | East Cooper Homeschool Band |
| 4 | SR | Clarinet | 18 | Hannah Culler | Charleston School of the Arts High School |
| 4 | SR | Clarinet | 19 | Lindsay Kramer | Wando High School |
| 4 | SR | Clarinet | 20 | Jordan Douglas | Charleston School of the Arts High School |
| 4 | SR | Clarinet | 21 | Shaleshia Funn | Colleton County High School |
| 4 | SR | Clarinet | 22 | Jordyn Anderson | Summerville High School |
| 4 | SR | Clarinet | 23 | Ashley Sincoff | Summerville High School |
| 4 | SR | Clarinet | 24 | Melina Serratelli | Bluffton High School |
| 4 | SR | Clarinet | A1 | Samantha Rice | Charleston School of the Arts High School |
| 4 | SR | Clarinet | A2 | Irvin Espinoza | Ridgeland Hardeeville High School |
| 4 | SR | Clarinet | A3 | Victoria Wheeler | Fort Dorchester High School |
| 4 | SR | Clarinet | A4 | Jordan Kuzniak | Ashley Ridge High School |
| 4 | SR | Clarinet | A5 | Amari Marsh | Orangeburg Wilkinson Senior High School |
| 4 | SR | Clarinet | A6 | Luke Harrington | Ashley Ridge High School |
| 4 | SR | Clarinet | A7 | Michaela Bennett | Colleton County High School |
| 4 | SR | Bass Clarinet | 01 | Eric Hansen | Summerville High School |
| 4 | SR | Bass Clarinet | 02 | Ginny Merrill | Charleston School of the Arts High School |
| 4 | SR | Bass Clarinet | 03 | Rashad Gadson | Bluffton High School |
| 4 | SR | Bass Clarinet | 04 | Henry Green | West Ashley High School |
| 4 | SR | Alto Sax | 01 | Finn Mefford | Wando High School |
| 4 | SR | Alto Sax | 02 | Yuuki Garcia | Wando High School |
| 4 | SR | Alto Sax | 03 | Megan Ralfe | Wando High School |
| 4 | SR | Alto Sax | 04 | Tanner Kirk | Charleston School of the Arts High School |
| 4 | SR | Alto Sax | 05 | Jorge Chocobar | Fort Dorchester High School |
| 4 | SR | Alto Sax | 06 | Nicholas Yinger | Summerville High School |
| 4 | SR | Alto Sax | A1 | Keegan Winn | Wando High School |
| 4 | SR | Alto Sax | A2 | Paige Robertson | Wando High School |
| 4 | SR | Alto Sax | A3 | Briona Robinson | Fort Dorchester High School |
| 4 | SR | Tenor Sax | 01 | Ashton Courtney | Wando High School |
| 4 | SR | Tenor Sax | 02 | Emily Francisco | Ashley Ridge High School |
| 4 | SR | Tenor Sax | A1 | CJ McLellan | James Island Charter High School |
| 4 | SR | Bari Sax | 01 | Nandia Lowkie | Summerville High School |
| 4 | SR | Bari Sax | A1 | Jessica Bevins | Charleston School of the Arts High School |
| 4 | SR | Trumpet | 01 | Sienne Rodwell | Charleston School of the Arts High School |
| 4 | SR | Trumpet | 02 | Jacob Zetrouer | Wando High School |
| 4 | SR | Trumpet | 03 | Ava Juliano | May River High School |
| 4 | SR | Trumpet | 04 | West Law | Wando High School |
| 4 | SR | Trumpet | 05 | Tyler Saxton | Wando High School |
| 4 | SR | Trumpet | 06 | Daniel Putman | Wando High School |
| 4 | SR | Trumpet | 07 | Kevin Higgins | Summerville High School |
| 4 | SR | Trumpet | 08 | Alex Camp | Wando High School |
| 4 | SR | Trumpet | 09 | Katie Maxon | Wando High School |
| 4 | SR | Trumpet | 10 | Braeden Armbruster | Wando High School |
| 4 | SR | Trumpet | 11 | Cady Haller | Charleston School of the Arts High School |
| 4 | SR | Trumpet | 12 | Megan Newton | Colleton County High School |
| 4 | SR | Trumpet | 13 | Matthew Wagner | May River High School |
| 4 | SR | Trumpet | 14 | Chris Thomas | Fort Dorchester High School |
| 4 | SR | Trumpet | 15 | Amanda Lapin | Wando High School |
| 4 | SR | Trumpet | 16 | Liam Dixson | Wando High School |
| 4 | SR | Trumpet | A1 | Jarell Summersett | Charleston School of the Arts High School |
| 4 | SR | Trumpet | A2 | Nallely Macias | Ridgeland Hardeeville High School |
| 4 | SR | Trumpet | A3 | Payton Sanchez | Battery Creek High School |
| 4 | SR | Trumpet | A4 | Jordan Pate | Wando High School |
| 4 | SR | Trumpet | A5 | Gerren Davis | Ashley Ridge High School |
| 4 | SR | Trumpet | A6 | Frances Kuester | Charleston School of the Arts High School |
| 4 | SR | Trumpet | A7 | Logan Bailey | Colleton County High School |
| 4 | SR | Trumpet | A8 | William Forsyth | West Ashley High School |
| 4 | SR | Horn | 01 | Ashley Worth | Charleston School of the Arts High School |
| 4 | SR | Horn | 02 | Caitlin Brennan | Charleston School of the Arts High School |
| 4 | SR | Horn | 03 | Caroline Grace | Ashley Ridge High School |
| 4 | SR | Horn | 04 | Mikayla Wyandt | James Island Charter High School |
| 4 | SR | Horn | 05 | Sarah Ritter | James Island Charter High School |
| 4 | SR | Horn | 06 | Caroline Salisbury | Charleston School of the Arts High School |
| 4 | SR | Horn | 07 | Neftaly Gutierrez | Bluffton High School |
| 4 | SR | Trombone | 01 | Blake Bishop | Wando High School |
| 4 | SR | Trombone | 02 | Keven Shepperd | Burke High School |
| 4 | SR | Trombone | 03 | Tradd Saxton | Wando High School |
| 4 | SR | Trombone | 04 | Paul Johnson | Summerville High School |
| 4 | SR | Trombone | 05 | Jaclyn Normoyle | Fort Dorchester High School |
| 4 | SR | Trombone | 06 | Andrew Peters | Wando High School |
| 4 | SR | Trombone | 07 | DQ Vinson | James Island Charter High School |
| 4 | SR | Trombone | 08 | Tyler Smoak | Charleston School of the Arts High School |
| 4 | SR | Trombone | 09 | Hayden Dexter | Ashley Ridge High School |
| 4 | SR | Trombone | A1 | Ian Underkofler | Wando High School |
| 4 | SR | Trombone | A2 | Tim Lever | James Island Charter High School |
| 4 | SR | Trombone | A3 | Julian Gioia | Charleston School of the Arts High School |
| 4 | SR | Trombone | A4 | Morgan Beard | Charleston School of the Arts High School |
| 4 | SR | Trombone | A5 | Carson Archie | Charleston School of the Arts High School |
| 4 | SR | Euphonium | 01 | Matteo Medina | Wando High School |
| 4 | SR | Euphonium | 02 | Aiden Perkins | Wando High School |
| 4 | SR | Euphonium | 03 | Camila Dorst | Wando High School |
| 4 | SR | Euphonium | 04 | Drew Smuniewski | Palmetto Scholars Academy |
| 4 | SR | Euphonium | A1 | Dellaney Kramer | Wando High School |
| 4 | SR | Euphonium | A2 | Rory O’Toole | Wando High School |
| 4 | SR | Tuba | 01 | Micah Pearson | Charleston School of the Arts High School |
| 4 | SR | Tuba | 02 | Will Meares | Wando High School |
| 4 | SR | Tuba | 03 | Emma Lindsey | Wando High School |
| 4 | SR | Tuba | 04 | Edward Smalls | Wando High School |
| 4 | SR | Tuba | 05 | Zoe Lyons | Beaufort High School |
| 4 | SR | Tuba | 06 | Antonio Martinez | Lake Marion High School |
| 4 | SR | Tuba | 07 | Gilberto Costilla | Bluffton High School |
| 4 | SR | Tuba | 08 | Andrew Marx | Wando High School |
| 4 | SR | Tuba | A1 | Micheal Jaldin-Soto | West Ashley High School |
| 4 | SR | Tuba | A2 | Quinton Frazier | James Island Charter High School |
| 4 | SR | Tuba | A3 | Will Weston | Wando High School |
| 4 | SR | Percussion | 01 | Rachel Huggins | Summerville High School |
| 4 | SR | Percussion | 02 | Jim Wilborn | Wando High School |
| 4 | SR | Percussion | 03 | John Robinson | Wando High School |
| 4 | SR | Percussion | 04 | Anna Lewis | Wando High School |
| 4 | SR | Percussion | 05 | Alex Ruiz-Mora | Summerville High School |
| 4 | SR | Percussion | 06 | Malique Pope | Fort Dorchester High School |
| 4 | SR | Percussion | 07 | Aliah Gibson | James Island Charter High School |
| 4 | SR | Percussion | A1 | Milik Green | Edisto High School |
| 4 | SR | Percussion | A2 | Christopher Barnwell | Charleston School of the Arts High School |
| 4 | SR | Percussion | A3 | Maggie Packard | Wando High School |
| 4 | SR | Percussion | A4 | Rebekah Smith | Fort Dorchester High School |
| 4 | SR | Timpani | 01 | Kyle Allen | Ashley Ridge High School |
| 4 | SR | Timpani | A1 | Cameron Wescott | Charleston School of the Arts High School |