| Region | Level | Region Chair | Instrument | Name | School |
| 5 | CL | 01 | Flute | Godric Armstrong | West Florence High School |
| 5 | CL | 02 | Flute | Connor Vongsaly | Berkeley High School |
| 5 | CL | 03 | Flute | Bernard Amelia | Georgetown High School |
| 5 | CL | 04 | Flute | Elijah Chestnut | Aynor High School |
| 5 | CL | 05 | Flute | Peyton Taylor | Cheraw High School |
| 5 | CL | 06 | Flute | Timber Dietrich | Carolina Forest High School |
| 5 | CL | 07 | Flute | Hailey Jones | Cane Bay High School |
| 5 | CL | 08 | Flute | Lagan Lewis | Carolina Forest High School |
| 5 | CL | 09 | Flute | Madison Beckles | Carolina Forest High School |
| 5 | CL | 10 | Flute | London Hansen | Saint James High School |
| 5 | CL | 11 | Flute | Payton Watts | Carolina Forest High School |
| 5 | CL | 12 | Flute | Katy Lin | Cane Bay High School |
| 5 | CL | A01 | Flute | Rachel Blanthorn | Goose Creek High School |
| 5 | CL | A02 | Flute | Josefina Gomez | Central High School |
| 5 | CL | A03 | Flute | Julian Braecklein | Lakewood High School |
| 5 | CL | A04 | Flute | Mara-Rose Helgenberger | Darlington High School |
| 5 | CL | A05 | Flute | Danielle Macanas | Socastee High School |
| 5 | CL | A06 | Flute | Emily Vipperman | Sumter High School |
| 5 | CL | 01 | Oboe | Hayden Ledbetter | Stratford High School |
| 5 | CL | 02 | Oboe | Bryant Herrera | Stratford High School |
| 5 | CL | 03 | Oboe | Bailey Smith | Berkeley High School |
| 5 | CL | 04 | Oboe | Cloey Miller | Sumter High School |
| 5 | CL | A01 | Oboe | Emma Thomas | Mayo High School |
| 5 | CL | 01 | Bassoon | Jack Szymanski | Hanahan High School |
| 5 | CL | 02 | Bassoon | Bailey Clark | Stratford High School |
| 5 | CL | 03 | Bassoon | Cameron Keib | Stratford High School |
| 5 | CL | 04 | Bassoon | Ian Hand | Carolina Forest High School |
| 5 | CL | 01 | Clarinet | Lauren Baxter | Carolina Forest High School |
| 5 | CL | 02 | Clarinet | Lily Ross | Carolina Forest High School |
| 5 | CL | 03 | Clarinet | Jahdiel John Wharton | Berkeley High School |
| 5 | CL | 04 | Clarinet | Sang Pham | Manning High School |
| 5 | CL | 05 | Clarinet | Krista Kennedy | West Florence High School |
| 5 | CL | 06 | Clarinet | Brianna Fahey | Socastee High School |
| 5 | CL | 07 | Clarinet | Maria Evans | Wilson High School |
| 5 | CL | 08 | Clarinet | Jillian Hensard | Sumter High School |
| 5 | CL | 09 | Clarinet | Hanna-Grace Munn | Latta High School |
| 5 | CL | 10 | Clarinet | Taylor Ferguson | South Florence High School |
| 5 | CL | 11 | Clarinet | Mikalah Atkins | Stratford High School |
| 5 | CL | 12 | Clarinet | Cassandra Burnett | Cane Bay High School |
| 5 | CL | 13 | Clarinet | Gavin Riddick | Sumter High School |
| 5 | CL | 14 | Clarinet | Kori Rouse | Wilson High School |
| 5 | CL | 15 | Clarinet | Nyshayla Cade | Mayo High School |
| 5 | CL | 16 | Clarinet | Ashlyn Mouzon | Hanahan High School |
| 5 | CL | 17 | Clarinet | Kiersten Phillips | Mayo High School |
| 5 | CL | 18 | Clarinet | Ayreona Garrett | Darlington High School |
| 5 | CL | 19 | Clarinet | Gabriela Pariso de Abreu Scarpini | Socastee High School |
| 5 | CL | 20 | Clarinet | Sarah Polson | Marlboro County High School |
| 5 | CL | 21 | Clarinet | Kanyiah Benjamin | Darlington High School |
| 5 | CL | 22 | Clarinet | Isabelle Boyd-Jackson | Wilson High School |
| 5 | CL | 23 | Clarinet | Kamrynne Gregg | Mayo High School |
| 5 | CL | 24 | Clarinet | Emery Mingacci | Stratford High School |
| 5 | CL | A01 | Clarinet | Dalton Dang | Cane Bay High School |
| 5 | CL | A02 | Clarinet | Logan James | Hanahan High School |
| 5 | CL | A03 | Clarinet | Kiana McCullen | Hartsville High School |
| 5 | CL | A04 | Clarinet | Abigail Ward | Carolina Forest High School |
| 5 | CL | A05 | Clarinet | Megan Lorick | Hanahan High School |
| 5 | CL | A06 | Clarinet | Davis Zaria | Georgetown High School |
| 5 | CL | A07 | Clarinet | Reed Kayla | Georgetown High School |
| 5 | CL | A08 | Clarinet | Rondell Davis | Darlington High School |
| 5 | CL | 01 | Bass Clarinet | Tristan King | Cane Bay High School |
| 5 | CL | 02 | Bass Clarinet | Amelia Lyden | Philip Simmons High School |
| 5 | CL | 03 | Bass Clarinet | Jessica Palmer | Stratford High School |
| 5 | CL | 04 | Bass Clarinet | Jamaria Jett | Darlington High School |
| 5 | CL | 01 | Contra Clarinet | Janaya Pernell | Dillon High School |
| 5 | CL | 02 | Contra Clarinet | Luis Lopez-Moreno | Saint James High School |
| 5 | CL | 01 | Alto Sax | Jaiden Collazo | Goose Creek High School |
| 5 | CL | 02 | Alto Sax | Dylan Kennedy | Hanahan High School |
| 5 | CL | 03 | Alto Sax | Dang Tran | Cane Bay High School |
| 5 | CL | 04 | Alto Sax | Connor Wiggins | West Florence High School |
| 5 | CL | 05 | Alto Sax | Fabien Wilson | West Florence High School |
| 5 | CL | 06 | Alto Sax | Joshua Raymundo | Sumter High School |
| 5 | CL | A01 | Alto Sax | Harrison Chandler | Goose Creek High School |
| 5 | CL | A02 | Alto Sax | Marshall Pigford | Hartsville High School |
| 5 | CL | A03 | Alto Sax | Kegan Catoe | Saint James High School |
| 5 | CL | 01 | Tenor Sax | Jayden Moreno | Stratford High School |
| 5 | CL | 02 | Tenor Sax | Parker Sullivan | Philip Simmons High School |
| 5 | CL | A01 | Tenor Sax | Johnathan Bowen | Carolina Forest High School |
| 5 | CL | 01 | Bari Sax | Emily Zeigler | Hanahan High School |
| 5 | CL | A01 | Bari Sax | Jaylyn Gore | Aynor High School |
| 5 | CL | 01 | Trumpet | Ryan Vasquez | S.C. Governor’s School for the Arts and Humanities – Region 5 |
| 5 | CL | 02 | Trumpet | Dristian Herrea-Diaz | Carolina Forest High School |
| 5 | CL | 03 | Trumpet | Tobias Sullivan | Waccamaw High School |
| 5 | CL | 04 | Trumpet | Wesley Ward | Stratford High School |
| 5 | CL | 05 | Trumpet | Ty Villar | Stratford High School |
| 5 | CL | 06 | Trumpet | Samantha Brigman | Latta High School |
| 5 | CL | 07 | Trumpet | Jonathan Neighbors | West Florence High School |
| 5 | CL | 08 | Trumpet | Kamryn Burns | North Myrtle Beach High School |
| 5 | CL | 09 | Trumpet | Grant Corde | Cane Bay High School |
| 5 | CL | 10 | Trumpet | Will Hamlin | Philip Simmons High School |
| 5 | CL | 11 | Trumpet | Kavaughn Green | Conway High School |
| 5 | CL | 12 | Trumpet | Simon Felix | Wilson High School |
| 5 | CL | 13 | Trumpet | Joanna Neri | Hartsville High School |
| 5 | CL | 14 | Trumpet | Gavin Connery | Saint James High School |
| 5 | CL | 15 | Trumpet | Amanda Hann | Saint James High School |
| 5 | CL | 16 | Trumpet | Kaleb Burroughs | West Florence High School |
| 5 | CL | A01 | Trumpet | Serenity Sonoda-Phommavong | Hanahan High School |
| 5 | CL | A02 | Trumpet | Colten Wiseley | North Myrtle Beach High School |
| 5 | CL | A03 | Trumpet | Budd Trammell | Aynor High School |
| 5 | CL | A04 | Trumpet | Judah Soler | Hanahan High School |
| 5 | CL | A05 | Trumpet | Lorelai Thompson | Cane Bay High School |
| 5 | CL | A06 | Trumpet | Manny O’Neill | Stratford High School |
| 5 | CL | A07 | Trumpet | T’Andre Lee | Stratford High School |
| 5 | CL | A08 | Trumpet | Bryce Jordan | Wilson High School |
| 5 | CL | 01 | Horn | Hannah Corde | Cane Bay High School |
| 5 | CL | 02 | Horn | Bea Acaylar | West Florence High School |
| 5 | CL | 03 | Horn | Kinsey Carraway | West Florence High School |
| 5 | CL | 04 | Horn | Jack Sticht | Stratford High School |
| 5 | CL | 05 | Horn | Charlotte Tilton | West Florence High School |
| 5 | CL | 06 | Horn | Joel Kuykendall | Stratford High School |
| 5 | CL | 01 | Trombone | Bailey Young | Sumter High School |
| 5 | CL | 02 | Trombone | Lily Purdy | Cane Bay High School |
| 5 | CL | 03 | Trombone | Hernandez Brandon | Georgetown High School |
| 5 | CL | 04 | Trombone | Jessica Parsley | Philip Simmons High School |
| 5 | CL | 05 | Trombone | Jesiah Baldwin | Marlboro County High School |
| 5 | CL | 06 | Trombone | Andon Buras | Cane Bay High School |
| 5 | CL | 07 | Trombone | Grate Nyla | Georgetown High School |
| 5 | CL | 08 | Trombone | Lillie Cavinee | North Myrtle Beach High School |
| 5 | CL | 09 | Trombone | Joshua Wernham | Stratford High School |
| 5 | CL | A01 | Trombone | Emmitt Bryant | Stratford High School |
| 5 | CL | A02 | Trombone | Zakiyah McClain | Darlington High School |
| 5 | CL | A03 | Trombone | Jose Ortiz Avalos | Cane Bay High School |
| 5 | CL | A04 | Trombone | Anthony Roscoe | Carolina Forest High School |
| 5 | CL | A05 | Trombone | Jackson Gordon | Hanahan High School |
| 5 | CL | 01 | Euphonium | Jake Montroy | S.C. Governor’s School for the Arts and Humanities – Region 5 |
| 5 | CL | 02 | Euphonium | Dylan Foster | Myrtle Beach High School |
| 5 | CL | 03 | Euphonium | Jack Hymas | Stratford High School |
| 5 | CL | 04 | Euphonium | Radek Beane | Carolina Forest High School |
| 5 | CL | A01 | Euphonium | Rachelle Masse | Stratford High School |
| 5 | CL | A02 | Euphonium | Caitlin Adams | Hanahan High School |
| 5 | CL | 01 | Tuba | Joshua Gayle | Stratford High School |
| 5 | CL | 02 | Tuba | Connor Sheppard | Darlington High School |
| 5 | CL | 03 | Tuba | Luke Woodall | Hanahan High School |
| 5 | CL | 04 | Tuba | Kristian Hennagan | Latta High School |
| 5 | CL | 05 | Tuba | Allison Amato | Berkeley High School |
| 5 | CL | 06 | Tuba | AJ Stevenson | Stratford High School |
| 5 | CL | 07 | Tuba | Karol Barbis | Carolina Forest High School |
| 5 | CL | 08 | Tuba | Sincere Dudley | Darlington High School |
| 5 | CL | 01 | Percussion | Taylor McCray | Cane Bay High School |
| 5 | CL | 02 | Percussion | Jackson Taylor | West Florence High School |
| 5 | CL | 03 | Percussion | Charlie Millis | Stratford High School |
| 5 | CL | 04 | Percussion | Alex Johnson | Stratford High School |
| 5 | CL | 05 | Percussion | Nathaniel Bruce | West Florence High School |
| 5 | CL | 06 | Percussion | Ashlyn Tessman | West Florence High School |
| 5 | CL | 07 | Percussion | Joseph Zapata Miranda | Goose Creek High School |
| 5 | CL | A01 | Percussion | Lauren Almony | Carolina Forest High School |
| 5 | CL | A02 | Percussion | Dibby Midgley | Cheraw High School |
| 5 | CL | A03 | Percussion | Richard RJ Hydrick | Berkeley High School |
| 5 | CL | A04 | Percussion | Jaydon Bledson | Sumter High School |
| 5 | CL | 01 | Timpani | Owen Carrillo | West Florence High School |
| 5 | CL | A01 | Timpani | Michael Posser | Carolina Forest High School |