| Region | Level | Instrument | Chair | Name | School |
| 5 | SR | Flute | 01 | Tiara Walton | Goose Creek High School |
| 5 | SR | Flute | 02 | Erica Bennett | Goose Creek High School |
| 5 | SR | Flute | 03 | Olivia Laird | Stratford High School |
| 5 | SR | Flute | 04 | Dani Zlotnicki | West Florence High School |
| 5 | SR | Flute | 05 | Lexi Mook | Stratford High School |
| 5 | SR | Flute | 06 | Rachel Rollins | Carolina Forest High School |
| 5 | SR | Flute | 07 | Jessica Martin | Hanahan High School |
| 5 | SR | Flute | 08 | Hannah Bridges | West Florence High School |
| 5 | SR | Flute | 09 | Seth DeMers | Stratford High School |
| 5 | SR | Flute | 10 | Ashley Leal-Diaz | Conway High School |
| 5 | SR | Flute | 11 | Camryn Cook | Loris High School |
| 5 | SR | Flute | 12 | Lauryn Brown | Goose Creek High School |
| 5 | SR | Flute | A01 | Cassidy Shannon | Saint James High School |
| 5 | SR | Flute | A02 | Lamika Cousar | Dillon High School |
| 5 | SR | Flute | A03 | Olivia Welsh | Waccamaw High School |
| 5 | SR | Flute | A04 | Jaclyn Graveline | Waccamaw High School |
| 5 | SR | Flute | A05 | Bailey Cox | Carolina Forest High School |
| 5 | SR | Flute | A06 | Tiana Nichols | Sumter High School |
| 5 | SR | Oboe | 01 | Rodericks Fobbs | Cane Bay High School |
| 5 | SR | Oboe | 02 | Amber Wellings | Carolina Forest High School |
| 5 | SR | Oboe | 03 | Maddie Hund | Stratford High School |
| 5 | SR | Oboe | 04 | Emma Carhart | Hanahan High School |
| 5 | SR | Oboe | A01 | Rachel Gunnis | Goose Creek High School |
| 5 | SR | Oboe | A02 | Nicole Tran | Cane Bay High School |
| 5 | SR | Bassoon | 01 | Katherine Jordan | Hartsville High School |
| 5 | SR | Bassoon | 02 | Victoria Donaldson | Cane Bay High School |
| 5 | SR | Bassoon | 03 | Andrew Gossett | Hanahan High School |
| 5 | SR | Clarinet | 01 | Kayla Stone | Hanahan High School |
| 5 | SR | Clarinet | 02 | Bailey Marks | Sumter High School |
| 5 | SR | Clarinet | 03 | Marinique Rolle | Goose Creek High School |
| 5 | SR | Clarinet | 04 | Cheyenne Hoover | Goose Creek High School |
| 5 | SR | Clarinet | 05 | Noah Ledbetter | Stratford High School |
| 5 | SR | Clarinet | 06 | Makayla Blanchard | Goose Creek High School |
| 5 | SR | Clarinet | 07 | Ashia Grant | Hanahan High School |
| 5 | SR | Clarinet | 08 | Kiara Edge | Dillon High School |
| 5 | SR | Clarinet | 09 | Sam Holberg | West Florence High School |
| 5 | SR | Clarinet | 10 | Abby West | Stratford High School |
| 5 | SR | Clarinet | 11 | Collin Creach | Hartsville High School |
| 5 | SR | Clarinet | 12 | LaTonja Gillespie | Goose Creek High School |
| 5 | SR | Clarinet | 13 | Shobria Sowells | Dillon High School |
| 5 | SR | Clarinet | 14 | Virginia Libby | Sumter High School |
| 5 | SR | Clarinet | 15 | Imani Stuckey | Darlington High School |
| 5 | SR | Clarinet | 16 | Jayla Patterson | Hartsville High School |
| 5 | SR | Clarinet | 17 | Arionna Rawls | Mayo High School |
| 5 | SR | Clarinet | 18 | Claire Washburn | Saint James High School |
| 5 | SR | Clarinet | 19 | Helen Lee | Sumter High School |
| 5 | SR | Clarinet | 20 | Emmanuel Okodugha | Sumter High School |
| 5 | SR | Clarinet | 21 | Ja’nekqua Cabbagestalk | Sumter High School |
| 5 | SR | Clarinet | 22 | C. J. Mungin | Stratford High School |
| 5 | SR | Clarinet | 23 | Shemiah McKenzie | Lake City High School |
| 5 | SR | Clarinet | 24 | Sabria Washington | Sumter High School |
| 5 | SR | Clarinet | A01 | MyAshia Haynesworth | Wilson High School |
| 5 | SR | Bass Clarinet | 01 | Rebekah Holt | Carolina Forest High School |
| 5 | SR | Bass Clarinet | 02 | Daney Brickles | Berkeley High School |
| 5 | SR | Bass Clarinet | 03 | Zaleayia Robinson | Darlington High School |
| 5 | SR | Bass Clarinet | 04 | Matthew James | Sumter High School |
| 5 | SR | Bass Clarinet | A01 | Brantlee Gerald | Loris High School |
| 5 | SR | Bass Clarinet | A02 | Rylee Toth | Sumter High School |
| 5 | SR | Contra Clarinet | 01 | Zharia Roberts | Cane Bay High School |
| 5 | SR | Contra Clarinet | 02 | La-taurean Brigman | Dillon High School |
| 5 | SR | Alto Sax | 01 | Keagan Ashalintubbi | Cane Bay High School |
| 5 | SR | Alto Sax | 02 | Sessaly Mitchell-Nelson | Sumter High School |
| 5 | SR | Alto Sax | 03 | Sapaydia Rosales | Goose Creek High School |
| 5 | SR | Alto Sax | 04 | Hunter Cline | Waccamaw High School |
| 5 | SR | Alto Sax | 05 | Jasmine Brunson | Sumter High School |
| 5 | SR | Alto Sax | 06 | Trey Binnom | Hanahan High School |
| 5 | SR | Alto Sax | A01 | Maclain Freeman | Hanahan High School |
| 5 | SR | Alto Sax | A02 | Logan Borg | Goose Creek High School |
| 5 | SR | Alto Sax | A03 | Aiden El-Mereebi | Hanahan High School |
| 5 | SR | Tenor Sax | 01 | Jeremiah Nesbitt | Hanahan High School |
| 5 | SR | Tenor Sax | 02 | Emily Daly | Goose Creek High School |
| 5 | SR | Tenor Sax | A01 | Alexia Green | Dillon High School |
| 5 | SR | Bari Sax | 01 | Damiah Breeden | Dillon High School |
| 5 | SR | Trumpet | 01 | Ryan Sturgill | Hartsville High School |
| 5 | SR | Trumpet | 02 | Jose Machado | Socastee High School |
| 5 | SR | Trumpet | 03 | Jakob Susol | Hanahan High School |
| 5 | SR | Trumpet | 04 | Matthew Price | West Florence High School |
| 5 | SR | Trumpet | 05 | Danny Rugema | Goose Creek High School |
| 5 | SR | Trumpet | 06 | Khristopher Long | Dillon High School |
| 5 | SR | Trumpet | 07 | Mickayla Hamilton | Goose Creek High School |
| 5 | SR | Trumpet | 08 | Jacob Sturdivant | Cane Bay High School |
| 5 | SR | Trumpet | 09 | Nicholas Perales | Sumter High School |
| 5 | SR | Trumpet | 10 | Luke DeMers | Stratford High School |
| 5 | SR | Trumpet | 11 | Samantha Miller | Carolina Forest High School |
| 5 | SR | Trumpet | 12 | Bre’Asia McLean | Dillon High School |
| 5 | SR | Trumpet | 13 | David Dixon | Stratford High School |
| 5 | SR | Trumpet | 14 | Camryn Finley | Socastee High School |
| 5 | SR | Trumpet | 15 | Mauricio Melara | Goose Creek High School |
| 5 | SR | Trumpet | 16 | Hannah Miller | Waccamaw High School |
| 5 | SR | Trumpet | A01 | Zachery Fulmore | Lake City High School |
| 5 | SR | Trumpet | A02 | Alec Daniels | Latta High School |
| 5 | SR | Trumpet | A03 | Dakota Nealy | Carolina Forest High School |
| 5 | SR | Trumpet | A04 | Brendan Caluneo | Berkeley High School |
| 5 | SR | Trumpet | A05 | Jeylen Kirkland | Darlington High School |
| 5 | SR | Trumpet | A06 | Ely Hill | Chesterfield High School |
| 5 | SR | Trumpet | A07 | Beth Gabbey | Hartsville High School |
| 5 | SR | Trumpet | A08 | Cristian Yangco | Goose Creek High School |
| 5 | SR | Horn | 01 | Nicholas Howard | Sumter High School |
| 5 | SR | Horn | 02 | Thomas Gardner | Stratford High School |
| 5 | SR | Horn | 03 | Nicholas Wilson | Socastee High School |
| 5 | SR | Horn | 04 | Jillian Hinders | Cane Bay High School |
| 5 | SR | Horn | 05 | Jazmine Hazeres | Goose Creek High School |
| 5 | SR | Horn | 06 | Makayla Ard | Goose Creek High School |
| 5 | SR | Horn | 07 | Isabella Roman | Goose Creek High School |
| 5 | SR | Horn | 08 | Jeremy Palmer | Sumter High School |
| 5 | SR | Horn | A01 | Neal Barfield | Hartsville High School |
| 5 | SR | Trombone | 01 | Tatyana Sanders | Dillon High School |
| 5 | SR | Trombone | 02 | Connor Reich | Cane Bay High School |
| 5 | SR | Trombone | 03 | Raleigh McMillian | Myrtle Beach High School |
| 5 | SR | Trombone | 04 | Jerome Richardson | Hartsville High School |
| 5 | SR | Trombone | 05 | Dorien Steed | Hanahan High School |
| 5 | SR | Trombone | 06 | Christian Shaffer | Cane Bay High School |
| 5 | SR | Trombone | 07 | Isaiah Williams | Stratford High School |
| 5 | SR | Trombone | 08 | Austin Lambert | Aynor High School |
| 5 | SR | Trombone | 09 | Jordan Hanson | Sumter High School |
| 5 | SR | Trombone | A01 | De’Anthony Cox | Hanahan High School |
| 5 | SR | Trombone | A02 | Joseph Mack | Manning High School |
| 5 | SR | Trombone | A03 | Joshua Jefferson | Mayo High School |
| 5 | SR | Trombone | A04 | Robbie Dixon | McBee High School |
| 5 | SR | Trombone | A05 | Cha’teria Smith | Darlington High School |
| 5 | SR | Bass Trombone | 01 | Elijah Justice | Cane Bay High School |
| 5 | SR | Euphonium | 01 | Jayrads Villanueva | Goose Creek High School |
| 5 | SR | Euphonium | 02 | Joshua Turner | Carolina Forest High School |
| 5 | SR | Euphonium | 03 | Matthew Shranko | West Florence High School |
| 5 | SR | Euphonium | 04 | Ethan Bautz | Saint James High School |
| 5 | SR | Euphonium | A01 | Caleb Conyers | Goose Creek High School |
| 5 | SR | Euphonium | A02 | Lyndon Bryant | Stratford High School |
| 5 | SR | Tuba | 01 | Hunter Thompson | Hartsville High School |
| 5 | SR | Tuba | 02 | Devon Clark | Hanahan High School |
| 5 | SR | Tuba | 03 | Leslie Paucar | Stratford High School |
| 5 | SR | Tuba | 04 | Malik Giles-Gregg | Darlington High School |
| 5 | SR | Tuba | 05 | Daniel Howard | Sumter High School |
| 5 | SR | Tuba | 06 | Briana Mouzon | S.C. Governor’s School for the Arts and Humanities – REGION 5 |
| 5 | SR | Tuba | 07 | Ron Williamson | West Florence High School |
| 5 | SR | Tuba | 08 | Bradley Britt | Aynor High School |
| 5 | SR | Tuba | A01 | Bryson Fulwood | North Myrtle Beach High School |
| 5 | SR | Tuba | A02 | Lauren Rowell | Dillon High School |
| 5 | SR | Tuba | A03 | Tamonte Byrd | Darlington High School |
| 5 | SR | Tuba | A04 | Kiersten Grubbs | Carolina Forest High School |
| 5 | SR | Percussion | 01 | Kevin Macaspac | Goose Creek High School |
| 5 | SR | Percussion | 02 | Christian Morris | Chesterfield High School |
| 5 | SR | Percussion | 03 | Justin Espiritu | Goose Creek High School |
| 5 | SR | Percussion | 04 | Aidan Gowe | Hanahan High School |
| 5 | SR | Percussion | 05 | Regis Wright | Timberland High School |
| 5 | SR | Percussion | 06 | Jalen Tingin | Goose Creek High School |
| 5 | SR | Percussion | 07 | Katriyon Mckie | Wilson High School |
| 5 | SR | Percussion | A01 | Altreze Gethers | Timberland High School |
| 5 | SR | Percussion | A02 | Kyle Chinn | Goose Creek High School |
| 5 | SR | Percussion | A03 | Taylor Winston | Sumter High School |
| 5 | SR | Percussion | A04 | Tess Humowitz | Waccamaw High School |
| 5 | SR | Timpani | 01 | Paul Carrotti | Carolina Forest High School |
| 5 | SR | Timpani | A01 | Keyshawn Matthews | Goose Creek High School |