| Region | Level | Instrument | Region Chair | Name | School |
| 6 | SR | Flute | 01 | Megan Turner | Dorman High School |
| 6 | SR | Flute | 02 | Cooper Taylor | Boiling Springs High School |
| 6 | SR | Flute | 03 | Alayna Phillips | James F. Byrnes High School |
| 6 | SR | Flute | 04 | Leighton Shehan | Clover High School |
| 6 | SR | Flute | 05 | Abby Inman | Union County High School |
| 6 | SR | Flute | 06 | Izzy Gauthier | York Comprehensive High School |
| 6 | SR | Flute | 07 | Abrianne Harrison-Shelton | Dorman High School |
| 6 | SR | Flute | 08 | Anabelle Ly | James F. Byrnes High School |
| 6 | SR | Flute | 09 | Samantha Teska | York Comprehensive High School |
| 6 | SR | Flute | 10 | Maggie Billings | York Comprehensive High School |
| 6 | SR | Flute | 11 | Kayla Ly | James F. Byrnes High School |
| 6 | SR | Flute | 12 | Michaela Greeff | Boiling Springs High School |
| 6 | SR | Flute | A01 | Sydney Martin | James F. Byrnes High School |
| 6 | SR | Flute | A02 | Laura-Steele Thorne | Chapman High School |
| 6 | SR | Flute | A03 | Carolyn Dulske | Boiling Springs High School |
| 6 | SR | Flute | A04 | Brooklyn Hicks | Chapman High School |
| 6 | SR | Flute | A05 | Kiera Johnson | Clover High School |
| 6 | SR | Flute | A06 | Eliza Petty | Spartanburg High School |
| 6 | SR | Oboe | 01 | Amir Rahmati | Clover High School |
| 6 | SR | Oboe | 02 | Whitney Durham | James F. Byrnes High School |
| 6 | SR | Oboe | 03 | Emma Cox | Laurens District 55 High School |
| 6 | SR | Oboe | 04 | Crystal White | Boiling Springs High School |
| 6 | SR | Oboe | A01 | Preston King | Chapman High School |
| 6 | SR | Bassoon | 01 | Abigail Turner | S.C. Governor’s School for the Arts and Humanities – Region 6 |
| 6 | SR | Bassoon | 02 | Steven Sparks | Boiling Springs High School |
| 6 | SR | Bassoon | 03 | Joey Lahoylahoy | Dorman High School |
| 6 | SR | Bassoon | 04 | Maggie Gossett | Clover High School |
| 6 | SR | Bassoon | A01 | Kalyn Baxter | James F. Byrnes High School |
| 6 | SR | Bassoon | A02 | Hayden Nesbitt | Boiling Springs High School |
| 6 | SR | Clarinet | 01 | Ellie Lawhorn | York Comprehensive High School |
| 6 | SR | Clarinet | 02 | Jada Turner | Union County High School |
| 6 | SR | Clarinet | 03 | Matthew O’Shea | York Comprehensive High School |
| 6 | SR | Clarinet | 04 | Amy Lamparter | Clover High School |
| 6 | SR | Clarinet | 05 | Quiara McBride | James F. Byrnes High School |
| 6 | SR | Clarinet | 06 | Ethan Hoang | Clover High School |
| 6 | SR | Clarinet | 07 | Olivia Roehl | James F. Byrnes High School |
| 6 | SR | Clarinet | 08 | Charlotte Hall | Clover High School |
| 6 | SR | Clarinet | 09 | Alec Pedersen | Dorman High School |
| 6 | SR | Clarinet | 10 | Ellen Jacobs | Dorman High School |
| 6 | SR | Clarinet | 11 | Emily Hastings | James F. Byrnes High School |
| 6 | SR | Clarinet | 12 | Vivian Gilman | Spartanburg Day School |
| 6 | SR | Clarinet | 13 | Bekah Jeffery | James F. Byrnes High School |
| 6 | SR | Clarinet | 14 | Cameron Hamrick | Broome High School |
| 6 | SR | Clarinet | 15 | Kolby Rea | Gaffney Senior High School |
| 6 | SR | Clarinet | 16 | Carissa Farris | Boiling Springs High School |
| 6 | SR | Clarinet | 17 | Valiyah Young | James F. Byrnes High School |
| 6 | SR | Clarinet | 18 | Jakira Wright | James F. Byrnes High School |
| 6 | SR | Clarinet | 19 | Jenna Gaffney | James F. Byrnes High School |
| 6 | SR | Clarinet | 20 | Kate Monaghan | Clover High School |
| 6 | SR | Clarinet | 21 | Catelyn Caughman | Clinton High School |
| 6 | SR | Clarinet | 22 | Angel Vega-Chavez | Dorman High School |
| 6 | SR | Clarinet | 23 | Valeria Reyna-Sifuentes | Clover High School |
| 6 | SR | Clarinet | 24 | Naomi Pacheco-Vera | York Comprehensive High School |
| 6 | SR | Clarinet | A01 | Sarah Grace Smyre | Dorman High School |
| 6 | SR | Bass Clarinet | 01 | Carlson Perrennoud | Boiling Springs High School |
| 6 | SR | Bass Clarinet | 02 | Marcus Gonzalez | Clover High School |
| 6 | SR | Bass Clarinet | 03 | Drake Dennis | Clover High School |
| 6 | SR | Bass Clarinet | 04 | Chase Sweat | Boiling Springs High School |
| 6 | SR | Bass Clarinet | A01 | Aaron Waddell | Dorman High School |
| 6 | SR | Contra Clarinet | 01 | Abigail Nix | James F. Byrnes High School |
| 6 | SR | Alto Sax | 01 | Ethan Button | Spartanburg High School |
| 6 | SR | Alto Sax | 02 | Richie Peer | Gaffney Senior High School |
| 6 | SR | Alto Sax | 03 | Katy Mae Crooks | Mid-Carolina High School |
| 6 | SR | Alto Sax | 04 | Alex Horton | Chapman High School |
| 6 | SR | Alto Sax | 05 | Ryan Quinones | Boiling Springs High School |
| 6 | SR | Alto Sax | 06 | Lawson Kyle | Spartanburg High School |
| 6 | SR | Alto Sax | A01 | Jasmin Mendoza | York Comprehensive High School |
| 6 | SR | Alto Sax | A02 | Charlise Green | York Comprehensive High School |
| 6 | SR | Alto Sax | A03 | Selena Acevedo | York Comprehensive High School |
| 6 | SR | Tenor Sax | 01 | Nick Burrus | Clover High School |
| 6 | SR | Tenor Sax | 02 | David Andryichuk | Chapman High School |
| 6 | SR | Tenor Sax | A01 | Zac Argentine | James F. Byrnes High School |
| 6 | SR | Bari Sax | 01 | Devin Ruppe | Gaffney Senior High School |
| 6 | SR | Bari Sax | A01 | Angelina Martin | Clover High School |
| 6 | SR | Trumpet | 01 | Connor Bruce | Dorman High School |
| 6 | SR | Trumpet | 02 | Richie Khouri | Boiling Springs High School |
| 6 | SR | Trumpet | 03 | Jackson Lipe | Blacksburg High School |
| 6 | SR | Trumpet | 04 | Will Isenhour | Clover High School |
| 6 | SR | Trumpet | 05 | Michael Mott | Clover High School |
| 6 | SR | Trumpet | 06 | Eduardo Yanez-Dera | Dorman High School |
| 6 | SR | Trumpet | 07 | John Emerson | James F. Byrnes High School |
| 6 | SR | Trumpet | 08 | Jakob Sawyer | Clover High School |
| 6 | SR | Trumpet | 09 | Elliott Wesson | Spartanburg High School |
| 6 | SR | Trumpet | 10 | MunTaiya Dillard | Spartanburg High School |
| 6 | SR | Trumpet | 11 | John Lawson | Dorman High School |
| 6 | SR | Trumpet | 12 | Noah Ennis | Clover High School |
| 6 | SR | Trumpet | 13 | Logan Yorick | Clover High School |
| 6 | SR | Trumpet | 14 | Naomi Major | Boiling Springs High School |
| 6 | SR | Trumpet | 15 | Cal Lee | James F. Byrnes High School |
| 6 | SR | Trumpet | 16 | Megan Garner | James F. Byrnes High School |
| 6 | SR | Trumpet | A01 | Brandon Bishop | Dorman High School |
| 6 | SR | Trumpet | A02 | Drew Blanton | Spartanburg Christian Academy |
| 6 | SR | Trumpet | A03 | Will Chastain | James F. Byrnes High School |
| 6 | SR | Trumpet | A04 | Matthew Mills | Boiling Springs High School |
| 6 | SR | Trumpet | A05 | Megan Stimman | Laurens District 55 High School |
| 6 | SR | Trumpet | A06 | Cisne Idrovo | Spartanburg High School |
| 6 | SR | Trumpet | A07 | Nathan Brown | Clover High School |
| 6 | SR | Trumpet | A08 | Elijah Colon | Dorman High School |
| 6 | SR | Horn | 01 | Bailey Turner | Clover High School |
| 6 | SR | Horn | 02 | Emma Mize | Boiling Springs High School |
| 6 | SR | Horn | 03 | Daniel Schulz | James F. Byrnes High School |
| 6 | SR | Horn | 04 | Shelby Arnold | Spartanburg High School |
| 6 | SR | Horn | 05 | Anna Edwards | Boiling Springs High School |
| 6 | SR | Horn | 06 | Charlotte King | James F. Byrnes High School |
| 6 | SR | Horn | 07 | Emily Anderson | Mid-Carolina High School |
| 6 | SR | Horn | 08 | Anna Becknell | Spartanburg High School |
| 6 | SR | Horn | A01 | Carmen Jolly | Dorman High School |
| 6 | SR | Horn | A02 | Benjamin Hatcher | Dorman High School |
| 6 | SR | Horn | A03 | Sierra Bostic | Gaffney Senior High School |
| 6 | SR | Horn | A04 | Shane Smith | Woodruff High School |
| 6 | SR | Trombone | 01 | Bre’Anna Ford | Dorman High School |
| 6 | SR | Trombone | 02 | Ethan Coble | Clover High School |
| 6 | SR | Trombone | 03 | Michael McDonald | James F. Byrnes High School |
| 6 | SR | Trombone | 04 | Jacob Lawson | Dorman High School |
| 6 | SR | Trombone | 05 | Nathaniel Robinson | Chapman High School |
| 6 | SR | Trombone | 06 | Philip Lebanno | York Comprehensive High School |
| 6 | SR | Trombone | 07 | Andrew Gergley | James F. Byrnes High School |
| 6 | SR | Trombone | 08 | Thomas Van Vleet | Spartanburg High School |
| 6 | SR | Trombone | 09 | Caden Greene | Chapman High School |
| 6 | SR | Trombone | A01 | Logan Applegate | York Comprehensive High School |
| 6 | SR | Trombone | A02 | Brynna Rost | Clover High School |
| 6 | SR | Trombone | A03 | Nathaniel McMillan | James F. Byrnes High School |
| 6 | SR | Trombone | A04 | Noah Galloway | Clover High School |
| 6 | SR | Trombone | A05 | Moises Rodriguez | York Comprehensive High School |
| 6 | SR | Euphonium | 01 | Colby Bonner | James F. Byrnes High School |
| 6 | SR | Euphonium | 02 | Shawn McCaul | Gaffney Senior High School |
| 6 | SR | Euphonium | 03 | Zach Rawlinson | Spartanburg Day School |
| 6 | SR | Euphonium | 04 | Kyle Ivey | York Comprehensive High School |
| 6 | SR | Euphonium | A01 | Nathaniel Hamms | Spartanburg High School |
| 6 | SR | Euphonium | A02 | Thomas Berry | Clover High School |
| 6 | SR | Tuba | 01 | Seth Milbry | Clover High School |
| 6 | SR | Tuba | 02 | Clayton Fravel | Boiling Springs High School |
| 6 | SR | Tuba | 03 | John Thomas Grant | James F. Byrnes High School |
| 6 | SR | Tuba | 04 | Acie Sistrunk | James F. Byrnes High School |
| 6 | SR | Tuba | 05 | Nickolas Cunningham | Clover High School |
| 6 | SR | Tuba | 06 | Jaden Opitz | Clover High School |
| 6 | SR | Tuba | 07 | Adam Leger | York Comprehensive High School |
| 6 | SR | Tuba | 08 | Gabe Hammonds | James F. Byrnes High School |
| 6 | SR | Tuba | A01 | Ben Rhyder | York Comprehensive High School |
| 6 | SR | Tuba | A02 | Omar Elbarky | Clover High School |
| 6 | SR | Tuba | A03 | Benjamin Labra | Dorman High School |
| 6 | SR | Bass Trombone | 01 | Chase Martin | Spartanburg High School |
| 6 | SR | Bass Trombone | A01 | Alex Pequignot | James F. Byrnes High School |
| 6 | SR | Percussion | 01 | Julia Graham | Spartanburg High School |
| 6 | SR | Percussion | 02 | Sofia Her | Chapman High School |
| 6 | SR | Percussion | 03 | Ashleigh Howard | James F. Byrnes High School |
| 6 | SR | Percussion | 04 | Sarah Grant | James F. Byrnes High School |
| 6 | SR | Percussion | 05 | Hugh McNulty | Dorman High School |
| 6 | SR | Percussion | 06 | Mattie Traylor | York Comprehensive High School |
| 6 | SR | Percussion | 07 | Logan Bauman | York Comprehensive High School |
| 6 | SR | Percussion | A01 | Lydia Gardner | James F. Byrnes High School |
| 6 | SR | Percussion | A02 | Lucas Brown | James F. Byrnes High School |
| 6 | SR | Percussion | A03 | Kaleb Young | James F. Byrnes High School |
| 6 | SR | Percussion | A04 | Daniel Larkin | Clover High School |
| 6 | SR | Timpani | 1 | Jacob Pearson | Converse College |
| 6 | SR | Timpani | A01 | Caleb Briggs | Oakbrook Preparatory School |