| Region | Level | Instrument | Region Chair | Name | School |
| 5 | SR | Flute | 01 | Erica Harrington | Cane Bay High School |
| 5 | SR | Flute | 02 | Angelina Lanza | Saint James High School |
| 5 | SR | Flute | 03 | Shegun Santos | Cheraw High School |
| 5 | SR | Flute | 04 | Chloe Hebert | Stratford High School |
| 5 | SR | Flute | 05 | Deborah Coates | Hanahan High School |
| 5 | SR | Flute | 06 | Rachel Byers | Carolina Forest High School |
| 5 | SR | Flute | 07 | Jerry Harmon | Stratford High School |
| 5 | SR | Flute | 08 | Wanda Hardy | Goose Creek High School |
| 5 | SR | Flute | 09 | Kailan McGee | Sumter High School |
| 5 | SR | Flute | 10 | Emma Hatfield | Stratford High School |
| 5 | SR | Flute | 11 | Jessica Weaver | South Florence High School |
| 5 | SR | Flute | 12 | Kody Morongell | Hartsville High School |
| 5 | SR | Flute | A01 | Melvin Mikell | Goose Creek High School |
| 5 | SR | Flute | A02 | Aurora Bruzual | Goose Creek High School |
| 5 | SR | Flute | A03 | Angel Coates | Hanahan High School |
| 5 | SR | Flute | A04 | Chad-Michael Allen | Stratford High School |
| 5 | SR | Flute | A05 | Ethan Marquez | Hanahan High School |
| 5 | SR | Oboe | 01 | Angie Evensen | Stratford High School |
| 5 | SR | Oboe | 02 | Kimiko Trevino | Stratford High School |
| 5 | SR | Oboe | 03 | Oben Ebai | Cane Bay High School |
| 5 | SR | Oboe | 04 | Eden Chowning | Carolina Forest High School |
| 5 | SR | Bassoon | 01 | Jalyse Iler | Stratford High School |
| 5 | SR | Bassoon | 02 | Ava McDonald | Philip Simmons High School |
| 5 | SR | Bassoon | 03 | Keely Thomas | Saint James High School |
| 5 | SR | Clarinet | 01 | Ashlynn McDowell | Stratford High School |
| 5 | SR | Clarinet | 02 | Anastasia Petrowski | Stratford High School |
| 5 | SR | Clarinet | 03 | Jordan Allen | Cane Bay High School |
| 5 | SR | Clarinet | 04 | Kaylee Sellers | Stratford High School |
| 5 | SR | Clarinet | 05 | Julia Perryman | Hanahan High School |
| 5 | SR | Clarinet | 06 | Candie Tran | Cane Bay High School |
| 5 | SR | Clarinet | 07 | Kaylee St. Amand | Stratford High School |
| 5 | SR | Clarinet | 08 | Vanessa Scotti | Carolina Forest High School |
| 5 | SR | Clarinet | 09 | Terrell Jackson | Goose Creek High School |
| 5 | SR | Clarinet | 10 | Pearson Midgley | Cheraw High School |
| 5 | SR | Clarinet | 11 | Jose Arana | Cane Bay High School |
| 5 | SR | Clarinet | 12 | Jamie Baker | Cane Bay High School |
| 5 | SR | Clarinet | 13 | Kanarian Temesgen | Berkeley High School |
| 5 | SR | Clarinet | 14 | Michael Knight | Saint James High School |
| 5 | SR | Clarinet | 15 | Alayna Williams | Carolina Forest High School |
| 5 | SR | Clarinet | 16 | Marquisha Johnson | Timberland High School |
| 5 | SR | Clarinet | 17 | Veronica Hari | Cane Bay High School |
| 5 | SR | Clarinet | 18 | Lashae Bunch | Darlington High School |
| 5 | SR | Clarinet | 19 | Ayanna Arrowood | Hartsville High School |
| 5 | SR | Clarinet | 20 | Tatiyana Gillespie | Goose Creek High School |
| 5 | SR | Clarinet | 21 | Stephen Carrasco | Carolina Forest High School |
| 5 | SR | Clarinet | 22 | Annie McMurray | Darlington High School |
| 5 | SR | Clarinet | 23 | Jabari Weaver | Sumter High School |
| 5 | SR | Clarinet | 24 | Julianne Lara-Rosa | Goose Creek High School |
| 5 | SR | Clarinet | A01 | Riley Parrish | Sumter High School |
| 5 | SR | Clarinet | A02 | Zach Kubitz | Cane Bay High School |
| 5 | SR | Clarinet | A03 | Veronica Weinberg | Goose Creek High School |
| 5 | SR | Clarinet | A04 | Hayden Dolen | Sumter High School |
| 5 | SR | Clarinet | A05 | Reagan Spivey | Cheraw High School |
| 5 | SR | Clarinet | A06 | Simmons NyAsia | Georgetown High School |
| 5 | SR | Clarinet | A07 | Brian Lengle | Cane Bay High School |
| 5 | SR | Clarinet | A08 | Ebony Austin | South Florence High School |
| 5 | SR | Bass Clarinet | 01 | Cameron Boerst | Philip Simmons High School |
| 5 | SR | Bass Clarinet | 02 | Joshua Williams | Carolina Forest High School |
| 5 | SR | Bass Clarinet | 03 | Caleb Washington | Marlboro County High School |
| 5 | SR | Bass Clarinet | 04 | Rileigh Johnson | Hartsville High School |
| 5 | SR | Contra Clarinet | 01 | Isabella Robinson | Sumter High School |
| 5 | SR | Contra Clarinet | 02 | Tonia Samuel | Darlington High School |
| 5 | SR | Contra Clarinet | A01 | Molly Bradbury | Carolina Forest High School |
| 5 | SR | Alto Sax | 01 | Jack Rose | Philip Simmons High School |
| 5 | SR | Alto Sax | 02 | Alan Rick | Cane Bay High School |
| 5 | SR | Alto Sax | 03 | Jordan Hutcherson | Socastee High School |
| 5 | SR | Alto Sax | 04 | Sibel Craft | Stratford High School |
| 5 | SR | Alto Sax | 05 | Terrell Townsend | Marlboro County High School |
| 5 | SR | Alto Sax | 06 | Owen Osborne | Goose Creek High School |
| 5 | SR | Alto Sax | A01 | Gael Fuentes-Matute | Stratford High School |
| 5 | SR | Alto Sax | A02 | Edwina Wang | Cane Bay High School |
| 5 | SR | Alto Sax | A03 | Alex Jaworski | Hartsville High School |
| 5 | SR | Tenor Sax | 01 | Trinity Bridges | Saint James High School |
| 5 | SR | Tenor Sax | 02 | Kierstyn Drayton | Central High School |
| 5 | SR | Bari Sax | 01 | William Gregory | Georgetown High School |
| 5 | SR | Bari Sax | A01 | Clayton Porter | Sumter High School |
| 5 | SR | Trumpet | 01 | Zackary Jordan | Carolina Forest High School |
| 5 | SR | Trumpet | 02 | Cody Miller | Stratford High School |
| 5 | SR | Trumpet | 03 | John Kerrigan | Cane Bay High School |
| 5 | SR | Trumpet | 04 | Tyler Odgers | Stratford High School |
| 5 | SR | Trumpet | 05 | Jacob Knotts | Socastee High School |
| 5 | SR | Trumpet | 06 | Landon Bunker | Aynor High School |
| 5 | SR | Trumpet | 07 | Sean Smith-Fauver | Stratford High School |
| 5 | SR | Trumpet | 08 | Christian Ensign | Hartsville High School |
| 5 | SR | Trumpet | 09 | Henry Dowe | Carolina Forest High School |
| 5 | SR | Trumpet | 10 | Isaac Hand | Carolina Forest High School |
| 5 | SR | Trumpet | 11 | James Nobles | Carolina Forest High School |
| 5 | SR | Trumpet | 12 | Sherrod Perez | Hanahan High School |
| 5 | SR | Trumpet | 13 | Jacob Swagel | Stratford High School |
| 5 | SR | Trumpet | 14 | Ryan Satnick | Socastee High School |
| 5 | SR | Trumpet | 15 | Jacob Perdue | Hartsville High School |
| 5 | SR | Trumpet | 16 | Andrew Kwant | Carolina Forest High School |
| 5 | SR | Trumpet | A01 | Sean Townsend | Marlboro County High School |
| 5 | SR | Trumpet | A02 | La’Zia Miles | Dillon High School |
| 5 | SR | Trumpet | A03 | Landon Evans | Carolina Forest High School |
| 5 | SR | Trumpet | A04 | Noah Foley | Cane Bay High School |
| 5 | SR | Trumpet | A05 | Yesenia Martinez | Saint James High School |
| 5 | SR | Trumpet | A06 | Zachary Peacock | Latta High School |
| 5 | SR | Trumpet | A07 | Jarod Ames | Stratford High School |
| 5 | SR | Horn | 01 | Branden Bell | Carolina Forest High School |
| 5 | SR | Horn | 02 | Bruno Pippolito | Carolina Forest High School |
| 5 | SR | Horn | 03 | Evan Debellis | Hartsville High School |
| 5 | SR | Horn | 04 | Samuel Hudman | Sumter High School |
| 5 | SR | Horn | 05 | Colin Uecker | Stratford High School |
| 5 | SR | Horn | 06 | Christian Anderson | Carolina Forest High School |
| 5 | SR | Horn | 07 | Micah Sullivan | Waccamaw High School |
| 5 | SR | Trombone | 01 | Braden Castro | West Florence High School |
| 5 | SR | Trombone | 02 | Jesse Peters | Cane Bay High School |
| 5 | SR | Trombone | 03 | Dominic Nunez | Hartsville High School |
| 5 | SR | Trombone | 04 | Isaiah Mendoza | Stratford High School |
| 5 | SR | Trombone | 05 | Nordin Lowery | Goose Creek High School |
| 5 | SR | Trombone | 06 | Kenneth McCrea | West Florence High School |
| 5 | SR | Trombone | 07 | Mira Degn | Goose Creek High School |
| 5 | SR | Trombone | 08 | Connor Holberg | West Florence High School |
| 5 | SR | Trombone | 09 | Emily Britt | Darlington High School |
| 5 | SR | Trombone | A01 | Gabriel Morris | Loris High School |
| 5 | SR | Trombone | A02 | Esdras Juarez | Cane Bay High School |
| 5 | SR | Trombone | A03 | Bernard Reese | Georgetown High School |
| 5 | SR | Trombone | A04 | Sean Smith | Dillon High School |
| 5 | SR | Trombone | A05 | Sabrina Wynn | Mayo High School |
| 5 | SR | Euphonium | 01 | Caleb Ford | Waccamaw High School |
| 5 | SR | Euphonium | 02 | Trevor Yarborough | Latta High School |
| 5 | SR | Euphonium | 03 | Nathan Phillips | Carolina Forest High School |
| 5 | SR | Euphonium | 04 | Michael Gardner | S.C. Governor’s School for Science & Mathematics |
| 5 | SR | Euphonium | A01 | Dylan Green | Stratford High School |
| 5 | SR | Euphonium | A02 | Kenneth Smith | Darlington High School |
| 5 | SR | Tuba | 01 | Chad Hall | Hartsville High School |
| 5 | SR | Tuba | 02 | Jakiedric Eagle | Dillon High School |
| 5 | SR | Tuba | 03 | Ryan Harriger | North Myrtle Beach High School |
| 5 | SR | Tuba | 04 | Taylor Held | Stratford High School |
| 5 | SR | Tuba | 05 | Tamera Benton | Darlington High School |
| 5 | SR | Tuba | 06 | Patrick Thomas | Hartsville High School |
| 5 | SR | Tuba | 07 | Justice Hicks | Berkeley High School |
| 5 | SR | Tuba | 08 | Michael Christmas | Cane Bay High School |
| 5 | SR | Tuba | A01 | Malachai Vazquez | Marlboro County High School |
| 5 | SR | Tuba | A02 | Grady Thames | Saint James High School |
| 5 | SR | Bass Trombone | 01 | Matthew Wiggins | Wilson High School |
| 5 | SR | Bass Trombone | A01 | Erik Lindstrom | Stratford High School |
| 5 | SR | Percussion | 01 | Cooper Whaley | Stratford High School |
| 5 | SR | Percussion | 02 | Devin Catangay | Stratford High School |
| 5 | SR | Percussion | 03 | Christian Miller | Carolina Forest High School |
| 5 | SR | Percussion | 04 | Jacob Rowell | Cane Bay High School |
| 5 | SR | Percussion | 05 | Corry Butts | Stratford High School |
| 5 | SR | Percussion | 06 | Khalil Washington | Goose Creek High School |
| 5 | SR | Percussion | 07 | Teondre Smalls | Goose Creek High School |
| 5 | SR | Percussion | A01 | Leslie Villagomez | Dillon High School |
| 5 | SR | Percussion | A02 | Chris Freeman | North Myrtle Beach High School |
| 5 | SR | Percussion | A03 | Jack Johnson | Cheraw High School |
| 5 | SR | Percussion | A04 | Rashawd Johnson | Goose Creek High School |
| 5 | SR | Timpani | 01 | Athena Gossett | Hanahan High School |
| 5 | SR | Timpani | A01 | Alicia Freeman | Stratford High School |