From Atlanta, Georgia, and points southwest, take I-85 to the I-185 exit. Follow I-185 into Greenville, I-185 will become Mills Avenue and then Church Street. Turn left onto Beattie Street. Beattie Street becomes College Street, then Buncombe Street. Follow this street eventually bearing right onto highway 25N (Poinsett Highway). Follow Poinsett Highway approximately 5 miles to the Furman University exit.

From Charlotte, North Carolina, and points northeast, take I-85 to Greenville. Follow I-385 into downtown. I-385 becomes E. North Street. As the traffic lanes divide into one-way streets, it becomes Beattie Street, then College Street, then Buncombe Street. Follow this street eventually bearing right onto highway 25N (Poinsett Highway). Follow Poinsett Highway approximately 5 miles to the Furman University exit.

From Columbia, South Carolina, and points southeast, take I-385 into downtown Greenville. I-385 becomes E. North Street. As the traffic lanes divide into one-way streets, it becomes Beattie Street, then College Street, then Buncombe Street. Follow this street eventually bearing right onto highway 25N (Poinsett Highway). Follow Poinsett Highway approximately 5 miles to the Furman University exit.